Inducted as a truly great player, Cassese enjoyed an All-American career at Duke, earning first team honors as a midfielder in 2002 and 2003 and second team accolades in 2001. He was also selected as the recipient of the Donald MacLaughlin Award as the national midfielder of the year in 2002. Cassese earned All-ACC honors three times (2001, 2002, 2003) and was named the ACC's Player of the Year in 2001 after leading Duke to the first of two straight league championships. He was a Tewaaraton Trophy finalist in both 2002 and 2003.
Cassese was a member of the 2002, 2006 and 2010 U.S. Men’s National Teams, winning the gold medal twice and also serving as captain for the 2010 squad. Cassese enjoyed a seven-year professional career in Major League Lacrosse, earning all-star honors in 2005 & 2006. He was selected as the MLL’s All-Star game MVP in 2006. Cassese was previously inducted into the US Lacrosse Long Island Metro Chapter’s Hall of Fame in 2013.