Frank was born in 1887 and was one of nine children. Henry went through Baltimore's public schools and attended Baltimore City College, graduating in 1905. Henry was a member of the Bancroft Literary Society; Athletic Association; lacrosse team 1902-1905; Board of Governors of Athletic Association in 1904 and 1905; class treasurer in 1902 and 1903.
Henry entered Johns Hopkins University as a member of the class of 1908, and was a member of Hopkins' varsity lacrosse team from 1906-1909. He was captain of the lacrosse team in 1909, and named as a member of the All-Time Johns Hopkins team.
Upon graduation in 1908, a committee visited his father and urged him to allow Henry to remain in college an extra year to give strength to the lacrosse team. They suggested he study law, which he did. Henry captained the team and they won the national championship that year - 1909.
The following year, Henry took over his father's business, "A. Frank & Sons", established by his grandfather in 1865. In 1910, Henry became active in settlement work and became a member of: Board of the Jewish Educational Alliance, 1910-1918; Board of Sinai Hospital, 1945-1953; Board of Associated Jewish Charities, 1945-46; 1949-54 President, Jewish Welfare Fund, 1949,1950; vice president, Baltimore Hebrew Congregation, 1925-50.
Henry Frank died in 1963.