In 1947, Eisenbrandt was the C. Markland Kelly Award recipient as the outstanding player in the MSA while at Poly. Fred then went on to achieve All-American honors as a midfielder at Duke. He earned Second Team All-American honors in 1951, and Honorable Mention in 1948 and 1950. He played in the 1951 North/South All-Star game before playing for Mt. Washington LC, where he co-captained one of the Open Champion teams.
Eisenbrandt then began an officiating career that spanned four decades. He was an active referee for 21 years, and served as National Chief Referee for nine years. He was the chief referee for the International Lacrosse Federation for four years, and was responsible for major rule revisions at the college and international levels.
Eisenbrandt received the Frenchy Julien Award in 1983 for outstanding service to lacrosse, and the Howdy Myers Lacrosse Man-of-the-Year Award in 1985.